منابع مشابه
Control of Gluconeogenesis in Rat Liver Cells
Control of gluconeogenesis from lactate was studied by titrating rat liver cells with lactate and pyruvate in a ratio of 1 O : l in a perifusion system. At different steady states of glucose formation, the concentration of key gluconeogenic intermediates was measured and plotted against gluconeogenic flux (Jglucoee). Complete saturation was observed only in the plot relating JglUcto the extrace...
متن کاملControl of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver.
Glucagon, epinephrine, norepinephrine, and cyclic AMP stimulated gluconeogenesis from lactate in perfused livers from fasted and fed rats. The stimulation was most marked when these agents were added to livers from fasted rats in which gluconeogenesis had become partially inactive during a preliminary perfusion without substrate. It is suggested that inactivation is consequent to the degradatio...
متن کاملglycolysis/gluconeogenesis in regenerating rat liver
Levels of mRNA for glucokinase, L-pyruvate kinase, fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase were analysed during liver regeneration. Levels of mRNA for glycolytic enzymes (glucokinase and L-pyruvate kinase) decreased rapidly after partial hepatectomy. Glucokinase mRNA increased at 16-24 h, returning to normal values after this time. L-pyruvate kinase mRNA recovered cont...
متن کاملGluconeogenesis in Neonatal Piglet Liver 1
The gluconeogenic capacity of livers from day old and 5-day-old piglets has been studied. The data show infused piglets and perfused livers convert lactate to glucose. Studies with isolated liver mitochondria show a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolypyruvate. Factors that affect accumulation of ma...
متن کاملTranscriptional control of gluconeogenesis in Aspergillus nidulans.
Aspergillus nidulans can utilize carbon sources that result in the production of TCA cycle intermediates, thereby requiring gluconeogenesis. We have cloned the acuG gene encoding fructose-1,6 bisphosphatase and found that expression of this gene is regulated by carbon catabolite repression as well as by induction by a TCA cycle intermediate similar to the induction of the previously studied acu...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44930-2